Opdivo + Yervoy combo — competitive update from the field

Company: Bristol Myers Squibb

Posted by OpdualagRep_BMS · March 22, 2026

Tags: pipeline, territory

BMS nivolumab/ipilimumab combo is holding its own in NSCLC despite Keytruda's dominance.

The tumor mutational burden story is still working in the right accounts.

My best oncologists appreciate having a mechanistically differentiated option for high TMB patients who aren't responding to anti-PD-1 monotherapy.

Pull-through isn't easy — REMS requirements, monitoring, the immune-related AE counseling burden — but the oncologists who've had good outcomes with the combo are very loyal.

If you're a new BMS rep going into this territory, know the TMB data cold.

That's where the conversation lives.

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